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About

Reliable integration of an ever-changing multitude of sensory inputs from the environment is the basis for learning and memory and shapes our behaviours. Our research aims to understand how sensory inputs are represented and computed to elucidate key principals of multisensory integration. To address this question, we combine state of the art circuit neuroscience tools like opto- and pharmacogenetics with single and two-photon imaging techniques to reveal computational frameworks of multisensory integration in deep brain areas and their effects on behaviour and learning.

 

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Publications

Google Scholar

Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A.

Amygdala neuronal ensembles dynamically encode behavioral states.
bioRxiv. 2018, https://doi.org/10.1101/425736

Krabbe S, Paradiso E, d’Aquin S, Bitterman Y, Xu C, Yonehara K, Markovic M, Gründemann J, Ferraguti F, Lüthi A.
Adaptive disinhibitory gating by VIP interneurons permits associative learning.
bioRxiv. 2018, https://doi.org/10.1101/443614

Duda J, Fauler M, Gründemann J, Liss B.
Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR.
Methods Mol Biol. 2018;1723:335-360.

Krabbe S, Gründemann J, Lüthi A.
Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning.
Biol Psychiatry. 2017 Oct 14. pii: S0006-3223(17)32062-0.

Douglass AM, Kucukdereli H, Ponserre M, Markovic M, Gründemann J, Strobel C, Alcala Morales PL, Conzelmann KK, Lüthi A, Klein R.
Central amygdala circuits modulate food consumption through a positive-valence mechanism.
Nat Neurosci. 2017 Oct;20(10):1384-1394.

Grewe BF, Gründemann J, Kitch LJ, Lecoq JA, Parker JG, Marshall JD, Larkin MC, Jercog PE, Grenier F, Li JZ, Lüthi A, Schnitzer MJ.
Neural ensemble dynamics underlying a long-term associative memory.
Nature. 2017 Mar 30;543(7647):670-675.

Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schnitzer MJ, Callaway EM, Lüthi A.
Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval.
Cell. 2016 Nov3;167(4):961-972.e16.

Vogel E, Krabbe S, Gründemann J, Wamsteeker Cusulin JI, Lüthi A.
Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits.
Neuron. 2016 Aug 3;91(3):644-51.

Gründemann J, Lüthi A.
Ensemble coding in amygdala circuits for associative learning.
Curr Opin Neurobiol. 2015 Dec;35:200-6.

Gründemann J, Clark BA.
Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.
Cell Rep. 2015 Sep 22;12(11):1715-22.

Wolff* SB, Gründemann* J, Tovote P, Krabbe S, Jacobson GA, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A.
Amygdala interneuron subtypes control fear learning through disinhibition.
Nature. 2014 May 22;509(7501):453-8.

Schlaudraff F, Gründemann J, Fauler M, Dragicevic E, Hardy J, Liss B.
Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson’s disease.
Neurobiol Aging. 2014 Oct;35(10):2302-15.

Senn V, Wolff SB, Herry C, Grenier F, Ehrlich I, Gründemann J, Fadok JP,
Müller C, Letzkus JJ, Lüthi A.
Long-range connectivity defines behavioral specificity of amygdala neurons.
Neuron. 2014 Jan 22;81(2):428-37.

Gründemann J, Schlaudraff F, Liss B.
UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson’s disease
brains.
Methods Mol Biol. 2011;755:363-74.

Gründemann J, Häusser M.
Neuroscience: A plastic axonal hotspot.
Nature. 2010 Jun 24;465(7301):1022-3.

Palmer LM, Clark BA, Gründemann J, Roth A, Stuart GJ, Häusser M.
Initiation of simple and complex spikes in cerebellar Purkinje cells.
J Physiol. 2010 May 15;588(Pt 10):1709-17.

Gründemann J, Schlaudraff F, Haeckel O, Liss B.
Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson’s disease.
Nucleic Acids Res. 2008 Apr;36(7):e38.

Ramirez A, Heimbach A, Gründemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J, Al-Din A, Hillmer AM, Karsak M, Liss B, Woods CG, Behrens MI, Kubisch C.
Hereditary parkinsonism with dementia is caused  by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.
Nat Genet. 2006 Oct;38(10):1184-91.

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Join us

We are always looking for highly motivated MSc / PhD students and postdocs to join the team. If you are interested, please don’t hesitate to contact us.

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Contact

Jan Gründemann, PhD
University of Basel
Department of Biomedicine
Klingelbergstrasse 50
4056 Basel, Switzerland
Email: jan.grundemann@unibas.ch

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